cure of Overdose: in the event of overdose, priorities are definitely the reestablishment of the patent and guarded airway and institution of assisted or managed air flow, if desired. utilize other supportive measures (such as oxygen and vasopressors) during the management of circulatory shock and pulmonary edema as indicated. Cardiac arrest or arrhythmias would require Sophisticated everyday living-assistance steps. Opioid antagonists, including naloxone, are specific antidotes to respiratory depression ensuing from opioid overdose. For clinically significant respiratory or circulatory depression secondary to opioid overdose, administer an opioid antagonist. Because the duration of opioid reversal is predicted to generally be a lot less than the duration of action of codeine in Codeine Sulfate Tablets, cautiously keep an eye on the affected individual until spontaneous respiration is reliably reestablished.

more help and checking may very well be required when prescribing for individuals at risk of opioid misuse.

lifestyle-Threatening Respiratory melancholy: tell people of the risk of lifestyle-threatening respiratory despair, which include data that the risk is finest when starting up Codeine Sulfate Tablets or when the dosage is elevated, Which it may arise even at suggested dosages.

To read the Patient information and facts (or other academic materials) that should feature their naloxone. Emphasize the necessity of undertaking this ahead of an opioid unexpected emergency takes place, so the individual and caregiver will know how to proceed.

Codeine is an opioid analgesic utilised to treat reasonable to intense soreness when the usage of an opioid is indicated.

Healthcare suppliers are strongly encouraged to accomplish a REMS-compliant education and learning application and to counsel individuals and caregivers on major risks, Protected use, and the value of looking through the Medication information with each prescription[see Warnings and safeguards (5.5)].

Anti-arrhythmics: codeine delays the absorption of mexiletine. The analgesic exercise of codeine is likely to be noticeably impaired by quinidine which impairs codeine metabolism.

Educate sufferers and caregivers on how to recognize respiratory despair and emphasize the significance of contacting 911 or receiving unexpected emergency health-related help immediately while in the party of a known or suspected overdose.

Withdrawal signs or symptoms can arise in breastfed infants when maternal administration of the opioid analgesic is stopped, or when breastfeeding is stopped.

Opioids may obscure the clinical training course inside of a affected individual by using a head damage. keep away from the use of Codeine Sulfate Tablets in people with impaired consciousness or coma.

In these people, mixed agonist/antagonist analgesics might decrease the analgesic effect and/or may possibly precipitate withdrawal indications.

The following really serious adverse reactions are explained, or explained in larger element, in other sections:

Hyperalgesia Hyperalgesia might be diagnosed In case the individual on lengthy-expression opioid therapy offers with increased ache. This could click here possibly be qualitatively and anatomically distinct from discomfort connected with disease progression or to breakthrough agony resulting from progress of opioid tolerance.

individual use of Naloxone with the unexpected emergency procedure of Opioid Overdose: explore The provision of naloxone for that emergency cure of opioid overdose with the client and caregiver and assess the likely have to have for access to naloxone, both of those when initiating and renewing remedy with Codeine Sulfate Tablets. tell individuals and caregivers about the different approaches to acquire naloxone as permitted by individual state naloxone dispensing and prescribing prerequisites or tips (e.g., by prescription, straight from a pharmacist, or as part of a community-dependent software). teach sufferers and caregivers on how to acknowledge respiratory depression and emphasize the significance of contacting 911 or receiving emergency professional medical support, regardless of whether naloxone is administered.